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Direct Physical Contact between Intercalated Cells in Distal Convoluted Tubule and the Afferent Arteriole in Mice
REN Hao * #,Xiaoyue Zhai
china medical university, histology and embryology
*Correspondence author
#Submitted by
Subject:
Funding: Specialized Research Fund for the Doctoral Program of Higher Education （No.No. 20102104120020）
Opened online: 2 January 2014
Accepted by: none
Citation: REN Hao,Xiaoyue Zhai.Direct Physical Contact between Intercalated Cells in Distal Convoluted Tubule and the Afferent Arteriole in Mice[OL]. [ 2 January 2014] http://en.paper.edu.cn/en_releasepaper/content/4578993
 
 
IDirect physical contact between the distal tubule and the afferent arteriole has been reported in rats and rabbits. The existence of a feedback mechanism termed cross-talk similar to that at macular densa has been proposed, which has significant impact on the control of systemic acid-base and electrolytes status. In the present study, we applied computer assisted 3D nephron tracing combined with immunohistochemistry to investigate such contacts in mice. With tracing, it became possible to determine whether the tubule and the contacting arteriole were associated to the same parent nephron or not. We investigated a total of 168 nephrons from 3 mouse kidneys. The majority of the nephrons (approximately 90% of the short-loop and 75% of the long-loop nephrons) had direct physical contact between their own afferent arteriole and distal tubule. These contacts always occurred at the last 10% of the distal convoluted tubule. Type nonA-nonB intercalated cells were always found in the tubular wall at the contact site. In conclusion, the present work demonstrated the existence of direct tubule-arteriole contact in mice. The close association of intercalated cells in the distal convoluted tubule suggests that these contacts may be the morphological basis for a cross-talk mechanism, which is potentially involved in the post-macula densa humeral pH and electrolyte regulation in the kidney.
Keywords:histology and embryology; 3D digital reconstruction; mouse kidney?????
 
 
 

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