Influence of Liquid Lipid Content on the Properties of Puerarin-loaded Lipid Nanoparticles

HU Xiaofen

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Influence of Liquid Lipid Content on the Properties of Puerarin-loaded Lipid Nanoparticles

HU Xiaofen * #

College of Bioengineering, Zhejiang Chinese Medical University, Hangzhou 310053

*Correspondence author

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Funding: none

Opened online:15 January 2014

Accepted by: none

Citation: HU Xiaofen.Influence of Liquid Lipid Content on the Properties of Puerarin-loaded Lipid Nanoparticles[OL]. [15 January 2014] http://en.paper.edu.cn/en_releasepaper/content/4581343

The present study described the fabrication and characterization of puerarin-loaded lipid nanoparticles with blends of glyceryl monostearate (solid lipid phase) and DELIOS? MCT (liquid lipid phase) as the lipid matrices. Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) were prepared via controlling the ratio of liquid lipid to solid lipid. The drug-lipid compatibility was evaluated via theoretical calculation of solubility parameters and X-ray diffraction analysis. The influence of liquid lipid content on the particle size, morphology, stability, drug loading properties of the lipid nanoparticles and in vitro release behavior of puerarin was investigated. Both SLN and NLC exhibited well stability and spherical shapes, and no significant difference in particle size occurred for the NLC series. The drug loading capacity (LC) and entrapment efficiency (EE) of the lipid nanoparticles were affected as increasing the liquid lipid content, and the presence of liquid lipid had a positive effect on improved drug payload. The in vitro release behavior of puerarin was intimately associated with the constituent of the lipid matrix. A sustained release of puerarin from NLC was observed in the selected experimental time window. The results of the current study displayed the application potential of NLC as nano-sized delivery carriers for puerarin.

Keywords:nanostructured lipid carriers (NLC); solid lipid nanoparticles (SLN); puerarin; drug loading; sustained release

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