| |
| Objective: To investigate the protective effect of total glycoside extract (TGE) from Ligustrum lucidum on concanavalin A-induced liver injury in mice. Methods: Con A injection into the tail vein caused hepatitis mice model via an intragastric feeding and TGE was meanwhile intervened, while the mice in control group were fed normal diet. At the end of experiments, all the mice were sacrificed to analyze serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), tumor necrosis factor-a (TNF-a) and interleukin-6 (IL-6) levels. Pathological changes of hepatic tissues were observed under microscope. Results: Compared to model group, serum ALT, AST, TNF-a and IL-6 levels exhibited an obvious reduction in TGE intervened mice (P<0.05). Conclusion: TGE has a significant preventive effect on Con A-induced hepatitis in mice, which can inhibit pro-inflammatory cytokines, relieve the peroxidation injury and improve liver function. |
|
| Keywords:Ligustri Lucidi Fructus; Concanavalin A; Hepatitis; Protective effect |
|
