Potassium Channels Depression is involved in the Apolipoprotein E4 enhanced Calcium Influx via N-Methyl-D-Aspartate receptor

Qin Ying; Yang Lifan; Weng Yuteng; Luo Xiaoli

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Potassium Channels Depression is involved in the Apolipoprotein E4 enhanced Calcium Influx via N-Methyl-D-Aspartate receptor

Qin Ying 1 * #,Yang Lifan 2,Weng Yuteng 2,Luo Xiaoli 2

1.East Hospital, Tongji University School of Medicine, 200092

2.Tongji University School of Medicine

*Correspondence author

#Submitted by

Subject:

Funding: National Nature Science Foundation of China （No.81200823), Specialized Research Fund for the Doctoral Program of Higher Education）

Opened online:10 February 2014

Accepted by: none

Citation: Qin Ying,Yang Lifan,Weng Yuteng.Potassium Channels Depression is involved in the Apolipoprotein E4 enhanced Calcium Influx via N-Methyl-D-Aspartate receptor[OL]. [10 February 2014] http://en.paper.edu.cn/en_releasepaper/content/4584364

Among many suggested mechanisms of the association between the ε4 allele of apoplipoprotein E gene (APOE) and Alzheimer's disease (AD), the present study focused on the link of apoE4 to Ca2+ homeostasis. On the acutely isolated hippocampal neurons, our observation showed that: 1) apoE4 increased the [Ca2+]i greatly and immediately. It was in a dose- and time- dependent manner, and irreversible; 2) removing Ca2+ from external solution abolished apoE4's effect on [Ca2+]i; 3) nicardipine showed little effect on apoE4-elicited [Ca2+]i increasing, while MK-801 almost blocked the apoE4-induced Ca2+ influx; and 4) pretreatment with K+ channel opener significantly reduced the apoE4-induced [Ca2+]i increasing. The results suggest that apoE4 increased [Ca2+]i by way of NMDA receptor channels but not L-type Ca2+ channels; and the depression of K+ channel activities was involved in this effects of apoE4.

Keywords:Apolipoprotein E4, calcium influx, potassium channel

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