The Peraration of  Self-Microemulsifying Drug Delivery System for Elemene and Its In vitro Evaluation

GU Mancang; QIAN Yafang; CHEN Jing

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The Peraration of Self-Microemulsifying Drug Delivery System for Elemene and Its In vitro Evaluation

GU Mancang 1 *,QIAN Yafang 2,CHEN Jing 1

1.College of Pharmaceutical Science, Zhejiang Chinese Medical University, Hangzhou 310053

2.Pharmaceutical preparation center, Zhejiang Hosptial of Traditional Chinese Medicine, Hangzhou, 310006

*Correspondence author

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Funding: The Specialized Research Fund for the Doctoral Program of Higher Education （No.No. 20113322120001 and No. 20103322120002）

Opened online:11 February 2014

Accepted by: none

Citation: GU Mancang,QIAN Yafang,CHEN Jing.The Peraration of Self-Microemulsifying Drug Delivery System for Elemene and Its In vitro Evaluation[OL]. [11 February 2014] http://en.paper.edu.cn/en_releasepaper/content/4584449

Our study developed a noval self-microemulsifying drug delivery system (SMEDDS) to enhance oral absorption of elemene and evaluated its oral bioavailability in rats. Pseudo-ternary phase diagrams were constructed to identify the efficient self-microemulsification region. SMEDDS formulations were further optimized by measurement of mean droplet size and emulsification time. The in vitro release profile of SMEDDS was determined in different aqueous media. The optimal formulation consisted of 10%Miglyol? 812, 41.7%Cremophor? EL, 8.3%Labrasol? ，20%Transcutol? P as well as 200 mg/g elemene, and demonstrated a higher release rate in simulated gastric fluid than emulsion and pure drug. Our results indicate that SMEDDS is a potential and promising drug delivery system for lipophilic Chinese herbal medicines, such as elemene.

Keywords:Self-microemulsifying drug delivery system; elemene; bioavailability

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