miR-203b: a novel regulator of MyoD expression in tilapia skeletal muscle

Yan Biao; Wang Zhenhua; Zhao Jinliang

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miR-203b: a novel regulator of MyoD expression in tilapia skeletal muscle

Yan Biao 1 *,Wang Zhenhua 2,Zhao Jinliang 1

1.College of Fisheries and Life Science, Shanghai Ocean University, Shanghai, 201306

2.College of Information Technology, Shanghai Ocean University, Shanghai, 201306

*Correspondence author

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Funding: Specialized Research Fund for the Doctoral Program of Higher Education of China （No.Grant No. 20123104120005 to B.Y.）

Opened online:21 October 2014

Accepted by: none

Citation: Yan Biao,Wang Zhenhua,Zhao Jinliang.miR-203b: a novel regulator of MyoD expression in tilapia skeletal muscle[OL]. [21 October 2014] http://en.paper.edu.cn/en_releasepaper/content/4613624

MyoD is one of the helix-loop-helix proteins regulating muscle-specific gene expression in tilapia. Tight regulation of the MyoD protein level is necessary for the precise regulation of skeletal muscle development. MicroRNAs (miRNAs) are a class of regulatory RNAs that post-transcriptionally regulate gene expression. An increasing amount of evidence has suggested that miRNAs play an important role in regulating skeletal muscle development. We reasoned that MyoD expression may be regulated by miRNAs. Predictions from bioinformatics have identified a putative miR-203b target site in the 3′-UTR of the MyoD gene. Interestingly, miR-203b expression is negatively correlated with MyoD expression, whereas miR-203b suppression leads to a significant increase in MyoD expression, thereby activating MyoD downstream genes. A 3′-UTR luciferase reporter assay further verifies the direct interaction between miR-203b and MyoD. Taken together, our results reveal a novel molecular mechanism inwhich miRNA participates in transcriptional circuits that regulate gene expression in tilapia skeletal muscle.?????

Keywords:Aquaclture, Nile tilapia, miR-203b, microRNA, skeletal muscle development.

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