Study on Serum Polyunsaturated Fatty Acids Level and Their Metabolic Enzyme Expression in a rat valproate-induced autism model

ZHAO Gang; GAO Jingquan; LIANG Shuang; WANG Xuelai; SUN Caihong; XIA Wei; LI Xiang; CAO Yonggang; WU Lijie

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Study on Serum Polyunsaturated Fatty Acids Level and Their Metabolic Enzyme Expression in a rat valproate-induced autism model

ZHAO Gang 1,GAO Jingquan 2,LIANG Shuang 1,WANG Xuelai 1,SUN Caihong 1,XIA Wei 1,LI Xiang 1,CAO Yonggang 3,WU Lijie 1 *

1.Department of Child and Adolescent Health, Public Health College, Harbin Medical University,Harbin 150081

2.Department of Nursing,Daqing Campus of Harbin Medical University,Daqing 163319

3.Department of Pharmacology,Daqing Campus of Harbin Medical University,Daqing 163319

*Correspondence author

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Funding: The National Natural Science Foundation of （No.81273094）, Specialized Research Fund for the Doctoral Program of Higher Education of China（No.20112307110004）

Opened online:17 December 2014

Accepted by: none

Citation: ZHAO Gang,GAO Jingquan,LIANG Shuang.Study on Serum Polyunsaturated Fatty Acids Level and Their Metabolic Enzyme Expression in a rat valproate-induced autism model[OL]. [17 December 2014] http://en.paper.edu.cn/en_releasepaper/content/4622840

To explore whether the drop in the levels of serum polyunsaturated fatty acids (PUFAs) in patients with autism is associated with their metabolic enzyme, we choose rats with their embryos exposed to sodium valproate (VPA) at the 12.5th embryonic day (E12.5) as the models for autism, and observe the serum PUFAs levels and its liver metabolic enzymes expression such as Δ5-desaturase, Δ6-desaturase and elongase (Elovl2) of VPA rats and rats in a control group on postnatal day 35 (PND35). We found that the serum PUFAs levels and its liver metabolic enzyme expression of VPA rats are significantly lower, and the manifestations are similar to the behavioral changes of autism and abnormal expressions of proteins related to apoptosis and hippocampus neuron injury. This indicates that the rats with embryos exposed to VPA at an early stage may reduce the synthesis of serum PUFAs through the down-regulation of expression of PUFAs metabolic enzyme, so that it induces nervous system injury and behavioral changes. This paper will be helpful to study and explore the causes of autism.

Keywords:Children and Adolescents Health; Autism; Animal model; PUFA; Metabolic enzyme; Valproic acid

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