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| The imidazole (im) derivative, [trans-RuIII(im)(DMSO)Cl4](Him), NAMI-A, (where Ru = ruthenium and DMSO = dimethylsulfoxide) has successfully completed I phase trial. The Ru complexes with imidazole and its derivatives have been widely used many field researches because the nitrogen atom(s) of imidazole or its derivatives can be deprotonated and can further bind the other metal ions into two-nuclear, three-neclear complexes or higher one-dimensional, two-dimensional, or three-dimensional frameworks. Thus, the current review gives a comprehensive mechanism of action of NH3-coordinated, imidazole-coordinated, areneimidazole-cooradinated, and biimidazole-coordinated Ru complexes, with the emphasis on their structure and application. These complexes are widely used in the whole fields of coordination chemical, medicinal chemical, physical chemical, catalytic chemistry, and supramolecular chemistry. Imidazole-based Ru complexes are very fascinating in these fields because of i) Ru intrinsic synthetic advantages and modular approach, ii) binding with DNA, albumin and transferrin, extracellular matrix, and enzymes, iii) the formation of hydrogen bond of imidazole, and iv) high catalytic activity for allylic alcohols into carbonyl derivates. The structure activity relationships, successful applications, and the perspectives for imidazoles-based Ru complexes will be discussed in detail in this review. |
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| Keywords:imidazolate; ruthenium; hydrogen bond; anticancer; supramolecular |
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