RhoGDIα negatively regulates the glioma stem cell maintenance through RhoA/ROCK1/FOXO1/Oct4 pathway

Wu Fan; Han Wei; Hu Peishan; Li Dengke; Hu Yan; Qi Yingjiao; Yin Bin; Jiang Tao; Yuan Jiangang; Peng Xiaozhong

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RhoGDIα negatively regulates the glioma stem cell maintenance through RhoA/ROCK1/FOXO1/Oct4 pathway

Wu Fan 1,Han Wei 1 #,Hu Peishan 1,Li Dengke 1,Hu Yan 1,Qi Yingjiao 1,Yin Bin 1,Jiang Tao 2,Yuan Jiangang 1,Peng Xiaozhong 1 *

1.State Key Laboratory of Medical Molecular Biology, Department of Molecular Biology and Biochemistry, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing 100005, China

2. Department of Neurosurgery, Beijing Tiantan Hospital, Beijing 100050, China

*Correspondence author

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Funding: 高等学校博士学科点专项科研基金新教师类资助课题（No.20131106120021)，‘973’项目）

Opened online:23 July 2015

Accepted by: none

Citation: Wu Fan,Han Wei,Hu Peishan.RhoGDIα negatively regulates the glioma stem cell maintenance through RhoA/ROCK1/FOXO1/Oct4 pathway[OL]. [23 July 2015] http://en.paper.edu.cn/en_releasepaper/content/4650242

Glioma stem cells (GSCs) are a subset of tumor cells that drive glioma initiation and progression. The molecular mechanisms underlying the maintenance of GSC are still poorly understood. Here we investigated the role of RhoGDIα in GSCs. Over-expression of RhoGDIα suppressed the self-renewal and promoted the differentiation of GSCs. Further data suggested RhoGDIα inhibited the transcription of Oct4 through RhoA/ROCK1/FOXO1 pathway. Moreover, inactivation of ROCK1 also decreased the self-renewal and Oct4 transcriptional activity, and rescued the effects caused by RhoGDIα knockdown. Our results indicate that RhoGDIα is involved in the maintenance of GSCs.

Keywords:GSCs; RhoGDIα; self-renewal; Differentiation; Oct4.

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