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The Toxic Actions and Pharmacological Activities of Veratramine
LYU Chunming #,ZHANG Ning *
Technology Laboratory Center, Shanghai University of Traditional Chinese Medicine
*Correspondence author
#Submitted by
Subject:
Funding: Research Fund for the Doctoral Program （No.Grant No. 20113107110012）
Opened online:12 November 2015
Accepted by: none
Citation: LYU Chunming,ZHANG Ning.The Toxic Actions and Pharmacological Activities of Veratramine[OL]. [12 November 2015] http://en.paper.edu.cn/en_releasepaper/content/4660115
 
 
The steroidal alkaloid veratramine shows a variety of toxic actions and pharmacological activities. It is believed that veratramine has cardiac activity, antitumor activity and central action. Veratramine has also been recognized as a 5-HT agonist. The mechanisms of these toxic actions and pharmacological activities were investigated. In previous reports, microbial biotransformation of veratramine was carried out with two types of fungi (Nocardia species ATCC 21145 and Cunninghamella echinulata). Rings A and B of veratramine were transformed and seven new metabolites were identified. The toxic actions and pharmacological activities of veratramine, the corresponding mechanisms together with the microbial biotransformation of veratramine are reviewed in this paper.
Keywords:Toxic actions, pharmacological activities, microbial biotransformation.
 
 
 

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