Epigenetic silencing of protocadherin 10 in colorectal cancer

ZHANG Jiawei; ZHONG Xian; SHEN Hong; ZHENG Shu

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Epigenetic silencing of protocadherin 10 in colorectal cancer

ZHANG Jiawei 1 #,ZHONG Xian 2,SHEN Hong 2,ZHENG Shu 1 *

1.Cancer Institute, The Second Affiliated Hospital, Zhejiang University School of Medicine , Hangzhou, Zhejiang 310009

2.Department of Medical Oncology, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, 310009

*Correspondence author

#Submitted by

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Funding: Specialized Research Fund for the Doctoral Program of Higher Education （No.No.20110101120123）

Opened online:22 December 2015

Accepted by: none

Citation: ZHANG Jiawei,ZHONG Xian,SHEN Hong.Epigenetic silencing of protocadherin 10 in colorectal cancer[OL]. [22 December 2015] http://en.paper.edu.cn/en_releasepaper/content/4669482

Colorectal cancer (CRC) is one of the leading malignant tumors in the world and known as a multi-step process resulting from the accumulation of both genetic and epigenetic alterations of the genome. Although the molecular mechanisms of its pathogenesis remain unclear, inactivation of tumor-suppressor genes (TSGs) through promoter methylation plays an important role in the development of CRC. Aberrant methylation is the most well-defined hallmark in CRC. Recently, epigenetic silencing of protocadherin 10 (PCDH10) was found, as a frequent and early event, in CRC. PCDH10 has been identified as an important tumor suppressor gene (TSG) with key roles of colorectal carcinogenesis, invasion and metastasis. The advantages of gene methylation as a target for detection and diagnosis in tumor tissues and body fluids have led to discovering non-invasive screening methods for CRC. This article aims mainly to review the epigenetic alteration of PCDH10 and the possibility of a non-invasive biomarker for CRC.

Keywords:DNA methylation; PCDH10; colorectal cancer

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