Ratiometric Electrochemiluminescent Immunosensor based on Mesocrystals and Biomimetic Catalyst for Tumor Marker

Zhang Qingrong; Xu Guifang; Gong Lingshan; Zhang Shupei; Yan Huixiang; LI Yilin; Chen Sihong; Dai Hong

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Ratiometric Electrochemiluminescent Immunosensor based on Mesocrystals and Biomimetic Catalyst for Tumor Marker

Zhang Qingrong #,Xu Guifang,Gong Lingshan,Zhang Shupei,Yan Huixiang,LI Yilin,Chen Sihong,Dai Hong *

College of Chemistry and Chemical Engineering, Fujian Normal University, Fuzhou 350007

*Correspondence author

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Funding: National Science Foundation of Fujian Province（No.2011J05020）, Fujian Normal University outstanding young teacher research fund projects（No.fjsdjk2012068）, Foundation of Fuzhou Science and Technology Bureau（No.2013-S-113）, NSFC （No.21205016）, Education Department of Fujian Province（No.JA14071, JB14036, JA13068）

Opened online: 8 March 2016

Accepted by: none

Citation: Zhang Qingrong,Xu Guifang,Gong Lingshan.Ratiometric Electrochemiluminescent Immunosensor based on Mesocrystals and Biomimetic Catalyst for Tumor Marker[OL]. [ 8 March 2016] http://en.paper.edu.cn/en_releasepaper/content/4679439

In this paper, a ratiometric electrochemiluminescent immunosensor based on octahedral anatase mesocrystals (OAM) support for the determination of alpha-fetal protein (AFP) was developed. And OAM with high porosity and large surface area was adopted to as affinity support to immobilize abounding antibodies of AFP (Ab). Luminol and potassium persulfate (K2S2O8) were chosen as promising ECL emitter units, due to the potential-resolved property and maximum emission wavelength-resolved property of them. Furthermore, CS-AgI was found to possess biomimetic catalyst activity, which could catalyze the decomposition of hydrogen peroxide that as the common coreactant both of luminol and K2S2O8 and thus the dual ECL responses was amplified. Upon the basis of the ratio of ECL intensities at two excitation potentials, this proposed ratiometric ECL strategy achieved ultrasensitive determination for the alpha-fetal protein via competitive immunoreaction.

Keywords: Ratiometric, ECL immunosensor, Octahedral anatase mesocrystals, Dual-signal amplification, Competitive immunoreaction.?????

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