MicroRNAs : New Regulators of IL-22

Zhou Lu; Ronghua Liu; Enyu Huang; Yiwei Chu

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MicroRNAs : New Regulators of IL-22

Zhou Lu,Ronghua Liu,Enyu Huang,Yiwei Chu * #

Department of Immunology, School of Basic Medical Sciences, and Biotherapy Research Center, Fudan University, Shanghai 200032, China.

*Correspondence author

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Funding: This work was supported by National Natural Science Foundation of China （No.31400772, 81273215), the Science and Technology Commission of Shanghai Municipality）

Opened online:23 May 2016

Accepted by: none

Citation: Zhou Lu,Ronghua Liu,Enyu Huang.MicroRNAs : New Regulators of IL-22[OL]. [23 May 2016] http://en.paper.edu.cn/en_releasepaper/content/4689180

Interleukin-22 (IL-22) is a cytokine which belongs to IL-10 family. It is produced by T helper 22 (Th22) cells, T helper 1 (Th1) cells, T helper 17 (Th17) cells, natural killer 22 (NK22) cells, natural killer T (NKT) cells, innate lymphoid cells (ILCs) and γδ T cells. IL-22 exerts its functions via binding to a heterodimeric transmembrane receptor complex consisting of IL-22R1 and IL-10R2. IL-22 mainly contributes to tissue repair and host defense. Transcription factors such as retinoid orphan receptor γt (RORγt) and signal transducer and activator of transcription 3 (STAT3) have been reported to play important roles in the regulation of IL-22. Recently, several studies have reported that microRNAs (miRNAs) emerged as powerful regulators of interleukins including IL-22. Here, we introduce the regulators of IL-22, particularly emphasized the miRNAs. ?????

Keywords:MicroRNAs; IL-22; Regulators.

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