Using Pharmacokinetic Method to study the significance of Herbaceous compatible of peony liquorice decoction

WANG Wenping; CAO Qichen; LI Xiaobin; WANG Huawei; YU Ming; SUI Xin; CAO Ying

Chinese︱Feedback︱Save this page

• Elaborating Academic Views 　　　　 • Exchanging Innovative Ideas
• Protecting Intellectual Properties 　　• Fast Sharing Science Papers

Sponsored by the Center for Science and Technology Development of the Ministry of Education
Supervised by Ministry of Education of the People's Republic of China

Home > Papers

Using Pharmacokinetic Method to study the significance of Herbaceous compatible of peony liquorice decoction

WANG Wenping 1 *,CAO Qichen 2,LI Xiaobin 3,WANG Huawei 2,YU Ming 2,SUI Xin 2 #,CAO Ying 2

1.Liaoning University of Traditional Chinese Medicine

2.The Affiliated Hospital of Liaoning University of TCM,Shenyang China 110032

3.Tianjin Institude of Industrial Biotechnology,Chinese Academy of Sciences,Tianjin China,300308

*Correspondence author

#Submitted by

Subject:

Funding: none

Opened online:30 May 2016

Accepted by: none

Citation: WANG Wenping,CAO Qichen,LI Xiaobin.Using Pharmacokinetic Method to study the significance of Herbaceous compatible of peony liquorice decoction[OL]. [30 May 2016] http://en.paper.edu.cn/en_releasepaper/content/4691054

Objective: To explore the rationality of herbaceous compatibility of peony liquorice decoction by peoniflorin and glycyrrhetinic acid's pharmacokinetic parameters in SD rats' plasma. Methods: A HPLC/MS/MS method was used to detect the concentration of peoniflorin and glycyrrhetinic acid in SD rats which were administrated with peony, liquorice or peony liquorice decoction separately. Results: Comparing with the single administration of peony or liquorice, the rats given with peony liquorice decoction the glycyrrhetinic acid in the plasma spent less time to reach the peak concentration and the Cmax also increased. What's more, the peoniflorin's peak concentration enhanced, and the relative bioavailability increased either. Conclusion: The liquorice promoted the absorption of peoniflorin in peony, enhanced its vitro concentration, thereby causing the peoniflorin's function stronger and more powerful. The peony has advance the time of glycyrrhetinic acid in liquorice and quantity which appears in intracorporal, causing its effect emerged rapidly.

Keywords:Peony liquorice decoction;Pharmacokinetic;Compatibility rule,;peoniflorin;glycyrrhetinic acid;HPLC/MS/MS

For this paper

● PDF (0B)
● Revision 0 　　
● Print this paper
● Recommend this paper to a friend
● Add to my favorite list

Saved Papers

Please enter a name for this paper to be shown in your personalized Saved Papers list

Tags

Add yours

Related Papers

Statistics

PDF Downloaded	47
Bookmarked	0
Recommend	0
Comments	Array

Submit your papers

Alert Name:
Alerting to:
Authentication email will be sent to your email address in 24 hours
Frequency:
Email Message Format:	Plain text Graphical(HTML)

Complete the form below and we will recommend the selected titles to your friends on your behalf. * Indicates a required field.
Your name*:
Your email address*:
Recipient's name*:
Recipient's email address*:
(multiple recipient's names and email addresses should be separated with semicolons)
Your comments:	I thought you would find the page(s) useful.

Your name:
Your email address:
Recipient's name:
Recipient's email address:
(multiple recipient's names and email addresses should be separated with semicolons)
Your comments:	I thought you would find this page useful.

Disclaimer: This message was sent to your friend using the "Send it to a friend" facility on the Sciencepaper Online’ WWW site, http://www.paper.edu.cn/en. The Sciencepaper Online is not responsible for the content of this email, and anything said in this email does not necessarily reflect the Sciencepaper Online's views.

	Check out RSS, or use RSS reader to subscribe this item

Saved Papers