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| Plakinidines is a class of marine bioactive substances found in recent years, which have significant biological activity, such as inhibition of colon cancer cells, anti-leukemia and so on. It is of great significance to carry out its all synthetic work because of its potential application value. In this paper, a simple synthetic route was designed, and the intermediate intermediates of pramipride were successfully synthesized by using nitrobenzene, Ullmann coupling, Friedel-Crafts cyclization and rearrangement four-step reaction with m-dichlorobenzene as raw material 9-methyl-2,4-nitro-5-chloroacridine. The main influencing factors of each step reaction were discussed, and the product structure was confirmed by NMR, MS and other methods.. |
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| Keywords:2,4-dinitro-9-methyl acridine; Plakinidines; Friedel-Crafts reaction; 1,3-dichlorobenzene; intermediate |
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