Emulsified Isoflurane Produces Cardiac Protection in a Dog Cardiopulmonary Bypass Model by Adding to Cardioplegia Solution

HUANG Han; ZHOU Cheng; LIU Jin

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Emulsified Isoflurane Produces Cardiac Protection in a Dog Cardiopulmonary Bypass Model by Adding to Cardioplegia Solution

HUANG Han 1,ZHOU Cheng 2,LIU Jin 3 * #

1.West China Second Hospital of Sichuan University

2.Lab of anesthesia & Critical Care Medicine, Translational Neuroscience Center, West China Hospital of Sichuan University

3.Department of Anesthesiology, Lab of Anesthesia & Critical Care Medicine, Translational Neuroscience Center, West China Hospital of Sichuan University

*Correspondence author

#Submitted by

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Funding: none

Opened online:27 April 2017

Accepted by: none

Citation: HUANG Han,ZHOU Cheng,LIU Jin.Emulsified Isoflurane Produces Cardiac Protection in a Dog Cardiopulmonary Bypass Model by Adding to Cardioplegia Solution[OL]. [27 April 2017] http://en.paper.edu.cn/en_releasepaper/content/4727672

This study investigated whether caridoplegia solution with Emulsified Isoflurane (EI) could improve cardiaoprotection in a dog CPB model of great similarity to clinical settings. Adult dogs were randomly assigned to receive one of the following cardioplegia solutions: St. Thomas with EI (group ST+EI), St. Thomas with 30% Intralipid (group ST+EL) and St. Thomas alone (group ST). The aorta was crossclamped for two hours followed by reperfusion for another two hours, during which cardiac output was measured and dosages of positive inotropic agent to maintain normal hemodynamics were recorded. Serum level of cardiac troponin I (cTnI) and CK-MB were measured. Deletion of cardiac mitochondrial DNA was examined at the end of reperfusion. Compared with ST, ST+EI decreased the requirement of dopamine support while animals receiving ST+EI had a significantly larger cardiac output. ST+EI reduced post-CPB release of cTnI and CK-MB. Mitochondrial DNA loss was observed in only one of the tested animals from group ST+EI while it was seen in all the tested animals from group ST+EL and ST. Addition of emulsified isoflurane into cardioplegia solution protects against myocardial ischemia reperfusion injury. This protective effect might be mediated by preserving mitochondrial ultrastructure and DNA integrity.

Keywords:Emulsified isoflurane; Cardioplegia solution; Dog model

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