Pathological lesion and the antigenic localization of highly pathogenic avian influenza virus in Sheldrake Ducks

LIU Xiaojing; ZHENG Shimin; SUN Zhengyang; GAO Xueli; LIU Chaonan

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Pathological lesion and the antigenic localization of highly pathogenic avian influenza virus in Sheldrake Ducks

LIU Xiaojing,ZHENG Shimin,SUN Zhengyang,GAO Xueli,LIU Chaonan * #

College of veterinary medicine, Northeast Agricultural University, Harbin 150030

*Correspondence author

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Funding: Doctoral Fund of Ministry of Education of China（No.20122325120005）

Opened online:19 May 2017

Accepted by: none

Citation: LIU Xiaojing,ZHENG Shimin,SUN Zhengyang.Pathological lesion and the antigenic localization of highly pathogenic avian influenza virus in Sheldrake Ducks[OL]. [19 May 2017] http://en.paper.edu.cn/en_releasepaper/content/4733275

In this paper, to determine the pathogenicity and antigen distribution of China early H5N1 highly pathogenic avian influenza virus (HPAIV) A/GS/LN/45/04, the Sheldrake ducks were inoculated via the nostrils. Infected ducks appeared depression, orticollis and nystagmus clinical signs, hematoxylin and eosin (HE) stain found multiple organs showed different degrees of pathological changes. In addition, by Immuno-histochemistry (IHC) stain found that A/GS/LN/45/04 virus could duplicated in multiple organs, especially in brain and pancreas. These results could provide some important theoretical basis for the further study of Chinese AIVs.

Keywords: highly pathogenic avian influenza; pathology; H5N1; Sheldrake ducks

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