Application prospect of traditional Chinese medicine Exocarpium Citri grandis in the prevention and treatment of COVID-19

Su Weiwei; Wang Yonggang; Li Peibo; Wu Hao; Zeng Xuan; Shi Rui; Zheng Yuying; Li Panlin; Peng Wei

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Application prospect of traditional Chinese medicine Exocarpium Citri grandis in the prevention and treatment of COVID-19

Su Weiwei 1 *,Wang Yonggang 2,Li Peibo 2,Wu Hao 2,Zeng Xuan 2,Shi Rui 2,Zheng Yuying 2,Li Panlin 2,Peng Wei 2

1.School of Life Sciences, Sun Yat-sen University, Guangzhou 510275;School of Life Sciences, Sun Yat-sen University, Guangzhou 510275;School of Life Sciences, Sun Yat-sen University, Guangzhou 510275;School of Life Sciences, Sun Yat-sen University, Guangzhou 510275;School of Life Sciences, Sun Yat-sen University, Guangzhou 510275;School of Life Sciences, Sun Yat-sen University, Guangzhou 510275;School of Life Sciences, Sun Yat-sen University, Guangzhou 510275;School of Life Sciences, Sun Yat-sen University, Guangzhou 510275;School of Life Sciences, Sun Yat-sen University, Guangzhou 510275

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Funding: This work was supported byApplied Science and Technology R&D Special Fund Project of Guangdong Province （No.No. 2015B020234004, No. 2016B020239003)）

Opened online:17 March 2020

Accepted by: none

Citation: Su Weiwei,Wang Yonggang,Li Peibo.Application prospect of traditional Chinese medicine Exocarpium Citri grandis in the prevention and treatment of COVID-19[OL]. [17 March 2020] http://en.paper.edu.cn/en_releasepaper/content/4751193

Exocarpium Citri grandis (ECG, called Huajuhong in Chinese) is traditional Chinese herbal medicine and has been used for the treatment of respiratory diseases for hundreds of years. Contained flavonoids have been documented to be the primary active components. Recently, ECG has been listed in a TCM formula in Guideline for the diagnosis and treatment of COVID-19 (Sixth Edition) in China. However, the efficacy and mechanism of ECG in the prevention and treatment of respiratory diseases have not been systematically reviewed. Hence, In this review, we summarized the efficacies of ECG and its pharmacologically active compound naringin in antitussive, expectorant, improving lung function, alleviating acute lung injury, attenuating pulmonary fibrosis, and enhancing antiviral immune response, so as to provide a reference for its clinical application.

Keywords:Exocarpium Citri grandis; naringin; COVID-19; application prospect.

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