A Threonine(27)-to-Proline(27) substitution in the signal peptide of Iron oxidase of Acidithiobacillus ferrooxidans decreases iron oxidation capacity

penghong; yangyu; qiuguanzhou; Yuehua HU

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A Threonine(27)-to-Proline(27) substitution in the signal peptide of Iron oxidase of Acidithiobacillus ferrooxidans decreases iron oxidation capacity

penghong 1,yangyu 2,qiuguanzhou 2,Yuehua HU 3

1. Central South University

2.South University

3.Central South University

*Correspondence author

#Submitted by

Subject:

Funding: 教育部博士点基金（No.20020533012）

Opened online:30 December 2005

Accepted by: none

Citation: penghong,yangyu,qiuguanzhou.A Threonine(27)-to-Proline(27) substitution in the signal peptide of Iron oxidase of Acidithiobacillus ferrooxidans decreases iron oxidation capacity[OL]. [30 December 2005] http://en.paper.edu.cn/en_releasepaper/content/4803

Two wild type strains of Acidithiobacillus ferrooxidans, which were called CMS and YTW respectively, were isolated from low-grade copper ores in China. The data of iron oxidation and growth rates shows that strain YTW was much lower iron oxidation capacity and longer generation time than strain CMS. To reveal these heterogeneous phenotypic characters, the iro gene encoding Iron oxidase, which catalyzed the first step of iron oxidation metabolism system, was amplified by PCR and sequenced for both strains. Sequence alignment showed that there was a Threonine(27) -to- Proline(27) substitution in the signal peptide of Iron oxidase for strain YTW. The protein secondary structure predicted that the substitution made a loop among the residue 26, 27 and 28. This substitution may affect the location and interaction of Iron oxidase in cellular membrane. The results implied that Proline(27) substitution in the signal peptide of Iron oxidase may be an important factor for heterogeneous iron oxidation capacity of iron oxidation metabolism system. Key words: Acidithiobacillus ferrooxidans; Iron oxidase; Signal peptide; Proline

Keywords: Acidithiobacillus ferrooxidans; Iron oxidase; Signal peptide; Proline

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