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| The aim of this study is to investigate the EEG characteristics in frequency domain in frontal lobe, occipital lobe and hippocampus, i.e. cognition-related cortex of synaptic dysfunction model rat. Firstly, synaptic dysfunction model was made via microinjecting Aβ1-40 into hippocampal CA1 area of rat. Morris water maze behavioral test performed to investigate the learning and memory function of model group. Secondly, EEG in the above areaa for two groups were recorded. The spectrum for two groups was performed and the characteristics in frequency domain were analyzed. Results are that (1) The average escape latency in 3rd, 4th, 5th and 6th training times of model group are higher than that of normal. The average escape latency of normal group had marked different between 2nd and 5th training time, while that of model group contrast between 2nd and 7th training time (P<0.05). Secondly, without platform, the platform quadrant time percentage of model group was lower than the control (P<0.05). (2) In model rat, α rhythm was slowing down; α-band power of EEG decreased with peek frequency left shifted nearly 2Hz. And the power of δ-band and θ-band in frontal lobe, occipital and hippocampus all increased with different extent, from 20% to 2-fold. The synaptic dysfunction model rats were made successfully by microinjecting Aβ1-40 method. The model rats show the decreased learning and memory dysfunction. EEG frequency spectrum features in model rat show slower alpha rhythm (frequency depressing) with power amplitude lower or loss, slow waves (delta and theta wave) increasing with higher power amplitude. These can be consistent with the EEG of Alzheimer’s disease patients. Such provide electrophysiological basis for further plasticity and nerve regeneration study on the impaired cortex with synaptic dysfunction. |
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| Keywords:rat model, EEG, characteristics in frequency domain, synaptic dysfunction |
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