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Effects of chronic morphine exposure on visual response variability and latency in cats
Zaiyang Long * #,Zhen Liang,Lihua He
School of Life Science, University of Science and Technology of China
*Correspondence author
#Submitted by
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Funding: 博士点基金（No.20040358046）
Opened online:17 December 2007
Accepted by: none
Citation: Zaiyang Long,Zhen Liang,Lihua He.Effects of chronic morphine exposure on visual response variability and latency in cats[OL]. [17 December 2007] http://en.paper.edu.cn/en_releasepaper/content/17066
 
 
Chronic morphine exposure results in a degradation of the functional properties of cortical neurons. However, little evidence has been shown about morphine’s effects on the variability of visual response. To investigate whether chronic morphine exposure influences variability, we compared neurons of lateral geniculate nucleus (LGN) in morphine- and saline-treated cats. We found LGN neurons exhibited significantly increased variability after morphine administration. It is known that variability might act as one of the factors affecting response latency. Therefore, we correlated increased variability and prolonged latency, and this study showed the change of variability might contribute to delayed response accompanied by morphine. Increased variability together with prolonged latency should contribute to functional degradation in cortical areas after chronic morphine exposure.
Keywords:lateral geniculate nucleus; morphine; trial-to-trial variability; response latency
 
 
 

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