Dynamic process of phagocytosis and fates of macrophages after their ingestion of apoptotic neutrophils

Wang Jiong; Huang Wei-Lin; Wang Cheng; Liu Rong-Yu

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Dynamic process of phagocytosis and fates of macrophages after their ingestion of apoptotic neutrophils

Wang Jiong #,Huang Wei-Lin,Wang Cheng,Liu Rong-Yu *

Department of Pulmonology, Anhui Geriatrics Institute, the First Affiliated Hospital of Anhui Medical University

*Correspondence author

#Submitted by

Subject:

Funding: 国家自然科学基金，教育部博士点基金（No.30670936,20050366002）

Opened online: 7 April 2008

Accepted by: none

Citation: Wang Jiong,Huang Wei-Lin,Wang Cheng.Dynamic process of phagocytosis and fates of macrophages after their ingestion of apoptotic neutrophils[OL]. [ 7 April 2008] http://en.paper.edu.cn/en_releasepaper/content/20167

Clearance of apoptotic neutrophils by macrophages is important for the successful resolution of acute inflammation and homeostasis. In this study, the dynamic process of phagocytosis of apoptotic neutrophils was measured in real time and special attention was paid to the fates of macrophages after their phagocytosis in vitro, we staged the recognition and tethering, internalization, digestion and exocytosis stages of phagocytosis of apoptotic neutrophils. Furthermore we found that some macrophages underwent cell death after their ingestion of apoptotic cells. The dead macrophages consisted of autophagy, apoptosis and oncosis as revealed by transmission electron microscopy and confocal microscopy combined with specific dyes. These results demonstrated that after ingestion of apoptotic neutrophils, macrophages might undergo autophagy and apoptosis. Autophagy of macrophage after ingestion of apoptotic cells may be one of the new mechanisms in immune response.

Keywords:macrophage neutrophil apoptosis phagocytosis cell death

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