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In vitro pancreas duodenal homeobox-1 enhances the differentiation of pancreatic ductal epithelial cells into insulin-producing cells
Liu Tao,Wang Chun-you *,Yu Feng,Gou Shan-miao,Wu He-shui,Xiong Jiong-xin,Zhou Feng
Department of Pancreatic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
*Correspondence author
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Funding: 教育部博士点基金,国家自然科学基金（No.20050487077,30571817）
Opened online: 8 April 2009
Accepted by: none
Citation: Liu Tao,Wang Chun-you,Yu Feng.In vitro pancreas duodenal homeobox-1 enhances the differentiation of pancreatic ductal epithelial cells into insulin-producing cells[OL]. [ 8 April 2009] http://en.paper.edu.cn/en_releasepaper/content/31194
 
 
AIM: To observe whether PDX-1 enhances the differentiation of pancreatic ductal epithelial cells into insulin-producing cells in vitro. METHODS: Rat ductal epithelial cells were transfected with recombination plasmids XlHbox8VP16. After transfection, the insulin content of secretion was detected by RIA. The insulin-producing cells were detected by Dithizon-staining. RESULTS: The production and the insulin secretion of insulin-producing cells differentiated from transfected pancreatic ductal epithelial cells were higher than the untransfected in vitro with significant difference (P<0.05). CONCLUSION: PDX-1 can promote rat pancreatic ductal epithelial cells to differentiate into insulin-producing cells obviously in vitro.
Keywords:Pancreatic ductal epithelial cells; Islet; Differentiation; Pancreas duodenal homeobox-1
 
 
 

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