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Traditional Chinese Medicine
Wang Chen 1 * #,Lu Jinggen 1,Yin Haoqiang 2
1.Longhua Hospital affiliated to Shanghai Traditional Chinese Medicine University
2.Longhua Hospital affiliated to Shanghai Traditional Chinese Medicine Univeristy
*Correspondence author
#Submitted by
Subject:
Funding: Doctoral Research Foundation of Higher Education （No.No.20093107110005）, Shanghai Science and Technology Committee Venus Project（No.No.10QA1406600）, Shanghai Mucicipal Education Commission Innovation research project（No.No.10ZZ77）
Opened online:22 December 2010
Accepted by: none
Citation: Wang Chen,Lu Jinggen,Yin Haoqiang.Traditional Chinese Medicine[OL]. [22 December 2010] http://en.paper.edu.cn/en_releasepaper/content/4397413
 
 
Aim: This study was designed to develop and treat with traditional Chinese medicine method of an experimental rat model of subcutaneous fistula induced by bacteria infection. Methods: A spring-gauze was surgically implanted into 24 male Sprague-Dawley (SD) rat's dorsal muscle, respectively. Then Staphylococcus aureus and Escherichia Coli mixed bacteria were injected into the spring-gauze. After 45days, all spring-gauzes were removed under anesthesia. X-ray and ultrasound were performed, enabling imaging fistula track assessment. Every rat was examined by a fistula probe and four rats were randomly selected for histological fistula tract assessment at the same time. Residual rats were randomly divided into in two groups. Group A treated with traditional Chinese medical method "thread-dragging therapy". Group B treated with Western medical method "fistulotomy". The healing time and body weights of two groups were compared. Results: At 45days imaging assessment showed a track with two openings in all rats and histological results proven lumen and surrounding granulation tissue with epithelium similar to that criteria and features of fistula in human being. The mean healing time of group A was shorter than group B with significant differences. The body weight of group A is heavier than group B at 7days after surgery and 14days after surgery respectively. Conclusions: A rat model with subcutaneous fistula induced by Staphylococcus aureus and Escherichia Coli mixed bacteria infection is easy and repeatable. Traditional Chinese medicine therapy "thread-dragging therapy" is less invasive and safe. [Key words] Subcutaneous fistula; Infected model; Traditional Chinese medicine; Thread-dragging therapy
Keywords:Subcutaneous fistula; Infected model; Traditional Chinese medicine; Thread-dragging therapy
 
 
 

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