Home > Papers

 
 
Inhibitory Activity of Alltride, Sodium Houttuyfonate and Berberine Hydrochloride on Mycobacterium Tuberculosis
JIANG Xin 1 * #,LU Chanyi 2
1.Shanghai university of T.C.M, Department of microbiology and immunology, Shanghai 201203
2.Institute of Genetics, Fudan University Shanghai 200433
*Correspondence author
#Submitted by
Subject:
Funding: 高等学校博士学科点专项科研基金资助课题（No.20093107120002）
Opened online:20 December 2010
Accepted by: none
Citation: JIANG Xin,LU Chanyi.Inhibitory Activity of Alltride, Sodium Houttuyfonate and Berberine Hydrochloride on Mycobacterium Tuberculosis[OL]. [20 December 2010] http://en.paper.edu.cn/en_releasepaper/content/4397485
 
 
Three Chinese medicine monomers alltride, sodium houttuyfonate and berberine hydrochloride, has been identified some activity against tuberculosis in clinic application in China. To explore the activity and mechanism of them against Mycobacterium tuberculosis and multidrug-resistant Mycobacterium tuberculosis, MICs of them were performed in vitro. Comparison between the proteomes of Mycobacterium tuberculosis H37Rv, treated with and without alltride, differential protein spots were measured by matrix assisted laser desorption ionization time of flight mass spectrometry (MOLDI-TOF-MS). Alltride had the same inhibitory activity on susceptible and multidrug resistant Mycobacterium tuberculosis. Sodium houttuyfonate and berberine hydrochloride were higher inhibitory concentration on multidrug resistant Mycobacterium tuberculosis than susceptible. Four protein spots were downregulated in Mycobacterium tuberculosis H37Rv treated with alltride and identified as Rv2032，Rv0780，Rv1611 and Rv1284 by MOLDI-TOF-MS. The four proteins might be the targets of alltride. These findings suggest the multidrug resistance mechanisms of Mycobacterium tuberculosis are effective to berberine hydrochloride and sodium houttuyfonate. The anti-Mycobacterium tuberculosis mechanisms of these two drugs might be the similar with the one of the existing anti-tuberculosis drugs. Mechanism of alltride was different from them, might be inhibition biosynthesis of some nucleic acid and amino acid.
Keywords:Mycobacterium tuberculosis; Chinese medicine monomer; MDR-TB
 
 
 

For this paper
  • ● PDF (0B)
  • ● Revision 0 　　
  • ● Print this paper
  • ● Recommend this paper to a friend
  • ● Add to my favorite list

    Saved Papers

    Please enter a name for this paper to be shown in your personalized Saved Papers list

Tags
Add yours

Related Papers

Statistics
PDF Downloaded 271
Bookmarked 0
Recommend 5
Comments Array
Submit your papers