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HuD regulates the cpg15 expression via its 3'-UTR
WANG Zhonghui 1,LI Shujing 2,Qi Yao 2,LIU Xiaoyan 2,ZHAO Jingjing 2,HAN Yu 2,CHEN Xianhua 2,XU Ping 2 *
1.State Key Laboratory of Medical Neurobiology，Fudan University
2.State Key Laboratory of Medical Neurobiology，Fudan University，Shanghai 200032, China
*Correspondence author
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Funding: National Natural Science Foundation of China （No.No. 30971464, 30470535, 30770661) and Research Fund for the Doctoral Program of Higher Education of China）
Opened online:19 January 2011
Accepted by: none
Citation: WANG Zhonghui,LI Shujing,Qi Yao.HuD regulates the cpg15 expression via its 3'-UTR[OL]. [19 January 2011] http://en.paper.edu.cn/en_releasepaper/content/4405989
 
 
The candidate plasticity related gene 15 (cpg15) plays important roles in neural development and plasticity. In the present study, we studied the role of the cpg15 3'-untranslated region (UTR) in regulating the expression of the gene. The results showed that the presence of the 3'-UTR significantly decreases, while the absence of the 3'-UTR increases the cpg15 expression, indicating that the 3'-UTR may be critical for regulation of cpg15 expression. In addition, HuD, a neural-specific RNA binding protein, increased the cpg15 expression, which depends on the presence of the 3'-UTR. The results suggest that HuD regulates the cpg15 expression via the 3'-UTR-mediated mechanism.
Keywords:cpg15; HuD; regulate; expression; 3'-UTR
 
 
 

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