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| Objective: A large number of studies demonstrated similar efficacy of drug-eluting stents (DES) on coronary lesions without calcification. However, few previous studies of DES for calcified lesion have been reported by limited sample size and mixed stent implanted, especially in real world patients. Therefore, we evaluated the effectiveness of sirolimus-eluting stent (SES) placement for the treatment of calcified lesions in a large cohort of real world practice. Methods: Consecutive 1632 patients with 1889 lesions treated with SES were enrolled. Lesions were divided into non-calcified groups (n=1087, lesions=1264) and mild-moderate calcified group (n=545, lesions=625) according to the lesion calcium. Lesions were subjected to quantitative coronary angiography (QCA) at immediately and 8 months following stenting. Results: Baseline characteristics were well balanced between the two groups. Angiographic follow-up at 8 months, the in-stent restenosis (ISR) and in-segment restenosis rate were similar in both groups. (ISR: 3.9% vs. 4.1%; p>0.05; in-segment restenosis: 8.7% vs. 9.8%, p>0.05). The target lesion revascularization (TLR) was no difference between the two groups (5.0% vs. 6.9%; p>0.05). In addition, the in-stent late loss and overall thrombosis rate were also similar in both groups (0.17?0.40 mm vs. 0.19?0.37 mm and 1.6% vs. 1.8%, p>0.05 respectively). Conclusion: In this real world study, the data suggested that successful implantation of SES for mild-moderate calcified coronary lesions might confer a similar favorable result in patients with coronary artery disease compared with non-calcified lesions. |
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| Keywords:Coronary calcified lesions; sirolimus-eluting stent;in-stent restenosis |
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