Absorption of Subdural Hematoma in a Modified Rat Model

Zhang Jianning; Wang Dong

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Absorption of Subdural Hematoma in a Modified Rat Model

Zhang Jianning 1,Wang Dong 2 * #

1.Department of Neurosurgery, Tianjin Neurological Institute, General Hospital, Tianjin Medical University

2.Tianjin Neurological Institute, General Hospital, Tianjin Medical University

*Correspondence author

#Submitted by

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Funding: Programs Foundation of Ministry of Education of China （No.20070062008）

Opened online: 6 April 2011

Accepted by: none

Citation: Zhang Jianning,Wang Dong.Absorption of Subdural Hematoma in a Modified Rat Model[OL]. [ 6 April 2011] http://en.paper.edu.cn/en_releasepaper/content/4419224

Studies on the pathophysiology of subdural hematoma (SDH) have primarily been focused on the acute phase, wherase the course of hematoma absorption remains poorly understood. In present study, we have modified a rat model of SDH to specifically investigate the correlation between neovascularization of hematom encapsulating membrane and cerebral tissue and hematoma absorption. The modified method significant improved the success rate from 10% to 71.4% and reduced surgical related injury. Depending on this more clinically relevant model of SDH, we demonstrated a non-linear reduction in reduction volume, with an initial slow rate in the first 6 days followed by rapid absorption. The neovascularization was characterized by the formation of arachnoid granulation-like structures at the interface between hematoma and encapsulating neomembrane. The recovery of sensorimotor deficits closely correlated with the neovascularization in the neomembranes, which dictates the rate of hematoma absorption. There was a close correlation between the increase in neovascularization and the absorption rate of SDH, suggesting that the development of neovasculature in the neomembrane plays a key role in hematoma absorption and measures to enhance the process could have therapeutic potentials.

Keywords:Surgery;subdural hematoma; Absorption; Rat model

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