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| Tartaric acid modified Raney nickel catalyst has been prepared by the in-situ modification and applied in the enantio-differentiating hydrogenation of methyl acetoacetate. The effects of varying the reaction temperature and pressure, solvent type, the amount of tartaric acid, additive and the reaction time on the optical yield and, in part, on the hydrogenation activity were systematically investigated. Various different types of Raney nickel catalysts were used in this paper. In order to deeply understand the inherent problems of the factor effects, various physico-chemical methods were employed in this research, such as inductive coupled high frequency plasma source (ICP), X-ray diffractometry (XRD) and so on. The highest optical yield of 61.6% was achieved over the improved T-1 RNi catalyst with an addition of 0.05 ml acetic acid under the optimal conditions. |
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| Keywords:In-situ modification; Enantio-differentiating; Raney nickel; Tartaric acid; Methyl acetoacetate |
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