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Ontogenic expression pattern and genetic polymorphisms of fatty acid transport protein 4 (FATP4) gene in chinese populations
WANG Yan 1,ZHU Qing 2,YANG Ling 2,YAO Yonggang 3,LIU Yiping 2 *
1.College of Animal Science and Technology, Sichuan Agricultural University
2.College of Animal Science and Technology, Sichuan Agricultural University,Ya'an 625014
3.Yunnan Province,Kunming Insititute of Zoology ,Kunming ,Yunnan650223
*Correspondence author
#Submitted by
Subject:
Funding: Program for New Century Excellent Telents in University, the Science Fund for Young Scholars in Sichuan Province (No.No. ZQ 026-017), The Research Fund for Doctoral Program of Higher Education of China (No.No. 20105103120006)
Opened online: 1 June 2011
Accepted by: none
Citation: WANG Yan,ZHU Qing,YANG Ling.Ontogenic expression pattern and genetic polymorphisms of fatty acid transport protein 4 (FATP4) gene in chinese populations[OL]. [ 1 June 2011] http://en.paper.edu.cn/en_releasepaper/content/4429621
 
 
Mountainous Black-boned chickens were used to test whether the single nucleotide polymorphisms (SNPs) and mRNA expression pattern of FATP4 gene may affect fatness and body composition, thus contribute to carcass traits. Quantitative real-time PCR analysis showed that the FATP4 mRNA had the highest expression in liver tissue compared to other tissues. The FATP4 mRNA levels presented a remarkable developmental change in leg muscle, breast muscle, and liver with increased age. Nine genetic variants were identified in FATP4 gene in all chicken samples and two SNPs (g.5608778C>T and g.5608814G>A in exon 6) were focused on to test as these two variations might be functional according to in silico analysis by the PANTHER. The results suggest that the FATP4 gene might play an important role in controlling chicken carcass traits and the two FATP4 gene SNPs may be useful for marker-assisted selection in chicken breeding program.
Keywords:chicken; FATP4; quantitative real-time PCR; SNPs; carcass traits
 
 
 

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