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Polymerized human placenta hemoglobin given before ischemia protects rat heart from ischemia reperfusion injury
Li Tao 1 * #,Zhou Ronghua 2,Wu Wei 3,Xiang Xujin 2,Zhu Da 2,Yang Chengmin 4,Li Yanyan 2,Liu Jin 2
1.Laboratory of Anesthesiology and Critical Care Medicine, West China Hospital, Sichuan University
2.Laboratory of Anesthesiology and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu 610041
3.Department of Anesthesiology, Chengdu Army General Hospital, Chengdu 610083
4.Institute of Blood Transfusion, Chinese Academy of Medical Sciences, Chengdu 610052
*Correspondence author
#Submitted by
Subject:
Funding: the Major Program of the clinical high and new technology of PLA (No.2010gxjs039), the China Postdoctoral Specialized Science Foundation(No.201003700), the Specialized Research Fund for the Doctoral Program of Higher Education(No.20100181120090), National Nature Science Foundation of China (No.30801083 and 81070117)
Opened online:23 August 2011
Accepted by: none
Citation: Li Tao,Zhou Ronghua,Wu Wei.Polymerized human placenta hemoglobin given before ischemia protects rat heart from ischemia reperfusion injury[OL]. [23 August 2011] http://en.paper.edu.cn/en_releasepaper/content/4439184
 
 
This study was to investigate whether polymerized human placenta hemoglobin (PolyPHb) given before ischemia protects in vivo rat heart function against ischemia/reperfusion (I/R) injury. Forty-five male Sprague-Dawley rats were randomly divided (n=15 per group) to sham group, control group (pretreatment with Lactated Ringer's solution) or PolyPHb group (pretreatment with 0.1gHb/kg PolyPHb). Rat hearts were subjected to 30-min ischemia by occlusion of left anterior descending, followed by 2-hr reperfusion. As compared to the control group, PolyPHb preserved cardiac function and reduced cardiac troponin-I release and histopathological changes. Therefore, PolyPHb pretreatment provided a profound cardioprotective effect on in vivo rat heart.
Keywords:hemoglobin-based oxygen carrier; pretreatment; cardiac function; ischemia/reperfusion injury
 
 
 

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