The research about REIC expression and its correlation with clinicopathological parameters of gastric carcinomas

Xu Xiaoyan; Xia Pu; Zheng Huachuan

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The research about REIC expression and its correlation with clinicopathological parameters of gastric carcinomas

Xu Xiaoyan 1,Xia Pu 2,Zheng Huachuan 2 *

1.Department of Pathophysiology, Institute of Pathology and Pathophysiology, College of Basic Medicine, China Medical University

2.Department of Biochemistry and Molecular Biology, Institute of Pathology and Pathophysiology, College of Basic Medicine, China Medical University, Shenyang, China

*Correspondence author

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Funding: Specialized Research Fund for the Doctoral Program of Higher Education（No.No. 20102104120026）, National Natural Scientific Foundation of China （No.No.81001093）, a Project Supported by Scientific Research Fund of Liaoning Provincial Education Department （No.No. L2010649）

Opened online: 3 November 2011

Accepted by: none

Citation: Xu Xiaoyan,Xia Pu,Zheng Huachuan.The research about REIC expression and its correlation with clinicopathological parameters of gastric carcinomas[OL]. [ 3 November 2011] http://en.paper.edu.cn/en_releasepaper/content/4447599

REIC is down-regulated in immortalized cell lines compared with the parental normal counterparts. It may inhibit colony formation, tumor growth, and induce the apoptosis. Here, REIC expression was examined in gastric carcinomas by RT-PCR, Western blot and immunohistochemistry, and compared with clinicopathological parameters of carcinoma. Immunohistochemically, REIC expression was negatively associated with tumor size, lymph node metastasis, dedifferentiation or poor prognosis of carcinoma. These results suggest that REIC expression may be a promising objective and effective marker to predict pathobiological behaviors and prognosis of gastric carcinoma.

Keywords:gastric carcinoma; REIC; prognosis

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