The effects of REIC overexpression on biological phenotypes of gastric carcinoma AGS cell line

Xu Xiaoyan; Xia Pu; Zheng Huachuan

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The effects of REIC overexpression on biological phenotypes of gastric carcinoma AGS cell line

Xu Xiaoyan 1,Xia Pu 2,Zheng Huachuan 2 *

1.Department of Pathophysiology, Institute of Pathology and Pathophysiology, College of Basic Medicine, China Medical University, ShenYang 110001

2.Department of Biochemistry and Molecular Biology, Institute of Pathology and Pathophysiology, College of Basic Medicine, China Medical University, Shenyang, China

*Correspondence author

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Funding: Specialized Research Fund for the Doctoral Program of Higher Education（No.No. 20102104120026）, National Natural Scientific Foundation of China （No.No.81001093）, a Project Supported by Scientific Research Fund of Liaoning Provincial Education Department（No.No. L2010649）

Opened online:11 November 2011

Accepted by: none

Citation: Xu Xiaoyan,Xia Pu,Zheng Huachuan.The effects of REIC overexpression on biological phenotypes of gastric carcinoma AGS cell line[OL]. [11 November 2011] http://en.paper.edu.cn/en_releasepaper/content/4448663

REIC is down-regulated in immortalized cell lines compared with the parental normal counterparts. It may inhibit colony formation, tumor growth, and induce the apoptosis. Here, gastric carcinoma AGS cell line transfected with REIC-expressing plasmid was subjected to the examination of phenotypes. REIC overexpression resulted in a low karyoplasmic ratio and proliferation, G1 arrest, high apoptosis, low migration, and invasion in AGS cells. These results suggest that REIC expression may be a promising objective and effective marker to predict pathobiological behaviors of gastric carcinoma.

Keywords:REIC; gastric carcinoma; carcinogenesis

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