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| Background Matrix metalloproteinases(MMPs) are considered to be essential for estimating the metastatic potential of tumor . Various studies examining the relationship between MMPs expression with the lymph-node involvement in Non-small cell lung cancer (NSCLC)patients have yielded inconclusive results. We try to explore whether there is an expressed value of MMPs in quantitating the risk of lymphatic metastasis of NSCLC. Patients and Methods The relation between MMPs and lymph node involvement (12 studies, n = 1875 patients )was examined. Fixed or random models are applied for estimation of the summarized odds ratio and 95% confidence intervals, including a test for homogeneity of the odds ratios(OR) of the studies. Results MMP-1, -2 was significantly associated with the presence of lymph node metastasis (MMP1: OR, 0.22; 95% CI [0.13-0.37]; P＜0.00001 / MMP2: OR, 0.65; 95% CI [ 0.51-0.83]; P=0.0007). MMP-7 and -9 was not (MMP7: OR, 0.81; 95% CI [0.58-1.13]; P=0.21 / MMP9: OR, 0.92; 95% CI [ 0.48-1.78]; P=0.81).
Conclusions Based on current data, expression of MMP-1 and -2 in the NSCLC patients might be associated with the involvement of lymphatic metastasis while MMP-7 and-9 might not be associated with the involvement. |
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| Keywords:Non-small cell lung cancer; matrix metalloproteinases ; meta-analysis ; odds ratio, lymphatic metastasis |
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