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Optimization of the synthesis of hydroxyl camphorsulfonamide derivatives as chiral ligands in the enantioselective addition of aldehyde
Xia Yamu* 1 *,Jiao Bin 2 #,Du Kangjian 2,Zhou Haitang 2
1.College of Chemical Engineering, Qingdao University of Science and Technology, ShanDong QingDao 266042
2.College of Chemical Engineering, Qingdao University of Science and Technology, Qingdao, shandong 266042, China
*Correspondence author
#Submitted by
Subject:
Funding: Specialized Research Fund for the Doctoral Program of High Education of China (No.No. 20093719120004), National Natural Science Foundation of Shandong (No.No. ZR2010HM023)
Opened online:30 March 2012
Accepted by: none
Citation: Xia Yamu*,Jiao Bin,Du Kangjian.Optimization of the synthesis of hydroxyl camphorsulfonamide derivatives as chiral ligands in the enantioselective addition of aldehyde[OL]. [30 March 2012] http://en.paper.edu.cn/en_releasepaper/content/4471857
 
 
The reaction conditions of the synthesis of hydroxycamphorsulfonamide derivatives, which have been proven to be useful chiral catalysts for enantioselective conjugate addition of dialkylzinc reagents to ketones, was discussed and optimized. The best results being obtained was using NaBH4 as reducing reagent, EtOH as solvent and the temperature at 0℃, what' more, larger substituents at N atom have better enantioselectivities and give higher product ratios. At last, some new types of chiral liands were synthesized.
Keywords:Optimization; Hydroxycamphorsulfonamide derivatives; Chiral ligand; Enantioselective addition
 
 
 

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