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Lactobacillus rhamnosus CCFM 1107 treatment ameliorates alcohol-induced liver injury in a mouse model of chronic alcohol feeding
CHI Feifei 1 #,TIAN Fengwei 2,WANG Gang 2,LIU Xiaoming 2,ZHANG Qiuxiang 2,ZHANG Hao 2,CHEN Wei 2 *
1.School of Food Science and Technology, Jiangnan University, JiangSu WuXi 214122
2.School of Food Science and Technology, Jiangnan University, Wuxi 214122
*Correspondence author
#Submitted by
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Funding: The “863”Project of China（No.No. 2011AA100901）
Opened online:26 March 2012
Accepted by: none
Citation: CHI Feifei,TIAN Fengwei,WANG Gang.Lactobacillus rhamnosus CCFM 1107 treatment ameliorates alcohol-induced liver injury in a mouse model of chronic alcohol feeding[OL]. [26 March 2012] http://en.paper.edu.cn/en_releasepaper/content/4472100
 
 
Lactobacillus rhamnosus CCFM 1107 was screened for high antioxidative activity from over 50 lactobacilli. The present study attempted to explore the in vivo protective properties of Lactobacillus rhamnosus CCFM1107 in alcoholic liver injury. A mouse model was induced by orally feeding alcohol by gavage when simultaneously treated with Lactobacillus rhamnosus CCFM 1107, the drug Hu-Gan-Pian, Lactobacillus rhamnosus GG, and Lactobacillus plantarum CCFM 1112 for 3 months. Biochemical analysis was performed for both serum and liver homogenate. Detailed intestinal flora and histological analyses were also carried out. Our results indicated that the administration of Lactobacillus rhamnosus CCFM 1107 signi?cantly inhibited the increase in the levels of serum aminotransferase and endotoxin, as well as the content of triglycercide and cholesterol in the serum and in the liver. Glutathione, glutathione peroxidase and superoxide dismutase were elevated while the levels of malondialdehyde were decreased. The enteric dysbiosis caused by alcohol was restored by increasing the numbers of both lactobacilli and bifidobacteria and decreasing the numbers of both enterococci and enterobacter. Histological analysis confirmed the protective effect of Lactobacillus rhamnosus CCFM 1107. In contrast to the other lactobacilli and to the drug administered in the study, we conclude that Lactobacillus rhamnosus CCFM 1107 provides a protective effect on alcoholic liver injury by reducing oxidative stress and restoring the intestinal flora.
Keywords:Lactobacillus rhamnosus; alcoholic liver injury; mice; oxidative stress
 
 
 

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