Synthesis, visible light photocleavage, antiproliferative and cellular uptake properties of ruthenium complex [Ru(phen)2(mitatp)]2+

Yu Huijuan; Yu Lin; Hao Zhifeng; Zhou Lihua; Xie Zhenming

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Synthesis, visible light photocleavage, antiproliferative and cellular uptake properties of ruthenium complex [Ru(phen)2(mitatp)]2+

Yu Huijuan 1 * #,Yu Lin 2,Hao Zhifeng 2,Zhou Lihua 2,Xie Zhenming 2

1.Faculty of Chemical Engineering and Light Industry, Guangdong University of Technology, GuangZhou 510006

2.Faculty of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou, 510006

*Correspondence author

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Funding: This work was supported by the Specialized Research Fund for the Doctoral Program of Higher Education, China （No.No. 20104420120006）, the Foundation for Distinguished Young Talents in Higher Education of Guangdong, China（No.No. LYM10068）

Opened online:26 April 2012

Accepted by: none

Citation: Yu Huijuan,Yu Lin,Hao Zhifeng.Synthesis, visible light photocleavage, antiproliferative and cellular uptake properties of ruthenium complex [Ru(phen)2(mitatp)]2+[OL]. [26 April 2012] http://en.paper.edu.cn/en_releasepaper/content/4474481

A new ruthenium complex [Ru(phen)2(mitatp)]2+ ( phen = 1,10-phenanthroline, mitatp = 5-methoxy-isatino[1,2-b]-1,4,8,9-tetraazatriphenylene) has been synthesized and characterized. The interaction of the complex with DNA has been studied and the results indicate that [Ru(phen)2(mitatp)]2+ could efficiently photocleave pBR322 DNA under irradiation at visible light and the singlet oxygen 1O2 was proved to be reactive species in the photocleavage process. The cytotoxicity has also been evaluated by MTT method, and [Ru(phen)2(mitatp)]2+ shows prominent anticancer activity against various cancer cells. Live cell imaging study and flow cytometric analysis demonstrate that the complex could cross cell membrane accumulating in the nucleus and inducing cell death by induction of G0/G1 cells cycle arrest and apoptosis.

Keywords:Ruthenium complex; DNA photocleavage; Cytotoxicity; Apoptosis

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