Synthesis, kinetic stabilities and potential anti-obesity activity of [Cr(III)(SA)(TETA)]ClO4

Liu Bin; Zhang Yujiao; Yang Binsheng

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Synthesis, kinetic stabilities and potential anti-obesity activity of [Cr(III)(SA)(TETA)]ClO4

Liu Bin 1 * #,Zhang Yujiao 2,Yang Binsheng 2

1.Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Institute of Molecular Science, Shanxi University, TaiYuan 030006

2.Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Institute of Molecular Science, Shanxi University, 030006, China

*Correspondence author

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Funding: Specialized Research Fund for the Doctoral Program of Higher Education （No.20091401120001）, the Natural Science Foundation of Shanxi Province（No.No. 2010011011-1）, National Natural Science Foundation of PR China（No.No. 21271122）

Opened online:18 December 2012

Accepted by: none

Citation: Liu Bin,Zhang Yujiao,Yang Binsheng.Synthesis, kinetic stabilities and potential anti-obesity activity of [Cr(III)(SA)(TETA)]ClO4[OL]. [18 December 2012] http://en.paper.edu.cn/en_releasepaper/content/4502896

In this paper one chromium(III) complexes, [Cr(III)(SA)(TETA)]ClO4 (I), was synthesized, and the structure was determined by X-ray crystallography (en=ethylenediamine, TETA= triethylenetetramine). Its kinetic stabilities in different media and different conditions (pH, H2O2, EDTA or visible light) were studied by means of UV-visible spectroscopy. Then its efficacy to prevent obesity was tested using a diet-induced obesity rat model. The primary results indicate that the compound effectively suppress the increases in body mass and adipose mass, without any noticeable toxic effect. It also prevented increases in the plasma triglyceride, cholesterol, and low density lipoprotein (LDL) concentrations.

Keywords:Chromium; salicylic acid; Kinetic stability; Diet-induced obesity

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