Alteration of Annexin A4 in rat fetuses with anorectal malformation and spina bifida aperta

FAN Yang; MIAO Jianing; YUAN Zhengwei

Chinese︱Feedback︱Save this page

• Elaborating Academic Views 　　　　 • Exchanging Innovative Ideas
• Protecting Intellectual Properties 　　• Fast Sharing Science Papers

Sponsored by the Center for Science and Technology Development of the Ministry of Education
Supervised by Ministry of Education of the People's Republic of China

Home > Papers

Alteration of Annexin A4 in rat fetuses with anorectal malformation and spina bifida aperta

FAN Yang #,MIAO Jianing,YUAN Zhengwei *

Key Laboratory of Health Ministry for Congenital Malformation, Shengjing Hospital, China Medical University, Shenyang,110004, P.R. China

*Correspondence author

#Submitted by

Subject:

Funding: 基金项目：高等学校博士点基金新教师基金（No.20092104120010）

Opened online: 9 January 2013

Accepted by: none

Citation: FAN Yang,MIAO Jianing,YUAN Zhengwei.Alteration of Annexin A4 in rat fetuses with anorectal malformation and spina bifida aperta[OL]. [ 9 January 2013] http://en.paper.edu.cn/en_releasepaper/content/4503323

Objective:To study the different expression proteins in fetal spinal cord with all-trans retinoic acid induced anorectal malformation and spina bifida rats by 2D-electrophoresis based proteomics. Methods: We studied the differently expressed proteins in fetal spinal cords of rats with anorectal malformation and spina bifida by 2D-electrophoresis based proteomics.Then Western blot analysis and real-time PCR were performed to verified the results of 2D-electrophoresis. Result: Annexin A4 was down-regulated in spinal cord of fetal rats with anorectal malformation and spina bifida by proteomics study, and the level of altered annexin A4 was related with the severity of malformation. This result was verified by western blot and real-time PCR analysis. Conclusions: In fetal spinal cord with all-trans retinoic acid induced anorectal malformation and spina bifida rats, annexin A4 expression decressed in both protein and genetic level, which might reflect the common neural injury in the two type of malformation.

Keywords:pediatric surgery;anorectal malformation;spina bifida aperta;annexin

For this paper

● PDF (0B)
● Revision 0 　　
● Print this paper
● Recommend this paper to a friend
● Add to my favorite list

Saved Papers

Please enter a name for this paper to be shown in your personalized Saved Papers list

Tags

Add yours

Related Papers

Other similar papers
● OsANN4 confers stress in...

Statistics

PDF Downloaded	245
Bookmarked	0
Recommend	5
Comments	Array

Submit your papers

Alert Name:
Alerting to:
Authentication email will be sent to your email address in 24 hours
Frequency:
Email Message Format:	Plain text Graphical(HTML)

Complete the form below and we will recommend the selected titles to your friends on your behalf. * Indicates a required field.
Your name*:
Your email address*:
Recipient's name*:
Recipient's email address*:
(multiple recipient's names and email addresses should be separated with semicolons)
Your comments:	I thought you would find the page(s) useful.

Your name:
Your email address:
Recipient's name:
Recipient's email address:
(multiple recipient's names and email addresses should be separated with semicolons)
Your comments:	I thought you would find this page useful.

Disclaimer: This message was sent to your friend using the "Send it to a friend" facility on the Sciencepaper Online’ WWW site, http://www.paper.edu.cn/en. The Sciencepaper Online is not responsible for the content of this email, and anything said in this email does not necessarily reflect the Sciencepaper Online's views.

	Check out RSS, or use RSS reader to subscribe this item

Saved Papers