Increased expression of tyrosine phosphatase SHP-2(PTPN11) in Helicobacter pylori-infected gastric cancer

JIANG Jing; KONG Fei; JING Meishan; CAO Xueyuan

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Increased expression of tyrosine phosphatase SHP-2(PTPN11) in Helicobacter pylori-infected gastric cancer

JIANG Jing 1 #,KONG Fei 2,JING Meishan 3,CAO Xueyuan 4 *

1.Division of Clinical Epidemiology, Jilin University First Hospital, ChangChun 130021

2.Division of Clinical Epidemiology, Jilin University First Hospital, Changchun 130021, Jilin Province, China

3.Division of Pathology, Jilin University First Hospital, Changchun 130021, Jilin Province,China

4.Department of Gastric and Colorectal Surgery, Jilin University First Hospital, Changchun 130021, Jilin Province, China

*Correspondence author

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Subject:

Funding: Specialized Research Fund for the Doctoral Program of Higher Education（No.No. 20090061120086）, National Natural Science Foundation of China （No.No.81072369 ）, Natural Science Foundation of China Jilin Province（No.No.200905131）

Opened online:27 December 2012

Accepted by: none

Citation: JIANG Jing,KONG Fei,JING Meishan.Increased expression of tyrosine phosphatase SHP-2(PTPN11) in Helicobacter pylori-infected gastric cancer[OL]. [27 December 2012] http://en.paper.edu.cn/en_releasepaper/content/4505643

AIM To explore the alteration of Tyrosine phosphatase SHP-2 (PTPN11) protein expression in gastric cancer and to assess its prognostic values. METHODS Three hundred and five consecutive cases of gastric cancer were enrolled in the study. SHP-2 expression was carried out in 305 gastric cancer specimen, of which 83 had paired adjacent normal gastric mucus samples using a tissue microarray immunohistochemistry method. Correlations were analyzed between expression levels of SHP-2 protein and tumor parameters or clinical outcomes. Serum anti- Helicobacter pylori (H.pylori) IgG was detected by enzyme-linked immunosorbent assay (ELISA) method. Cox proportional hazards model was used to evaluate prognostic values by compassion of the expression levels of SHP-2 and disease-specific survivals in patients. RESULTS SHP-2 staining was mainly found diffuse in the cytoplasm and the weak staining was also observed in the nucleus in gastric mucosa cells. 32.5% of normal epithelial specimen and 62.6% of gastric cancer specimen were identified to stain with SHP-2 antibody positively (P < 0.001). Though SHP-2 staining intensities were observed stronger in the H.pylori (+) group compared to the H.pylori (-) group, however, no statistically significant difference was found in the expression levels of SHP-2 between H.pylori (+) and H.pylori (-) gastric cancer (P=0.40). The SHP-2 expression in gastric cancer was not significantly associated with cancer stages, lymph node metastases, and distant metastasis of the tumors (P=0.34, P=0.17, P=0.52). Multivariate analysis demonstrated no correlation between SHP-2 expression and disease free survival (P=0.86). CONCLUSION Increased expression of SHP-2 protein in gastric cancer specimen suggesting the aberrant upregulation of SHP-2 protein might play an important role in the gastric carcinogenesis.

Keywords:Gastric cancer; SH2-containing protein tyrosine phosphatase 2; Expression; H. pylori

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