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Sequence Variants on Chromosomes 20q13.33, 11q23.3 and 5p15.33 are Associated with Glioma Susceptibility in a Chinese Population
Chen Hongyan 1 #,Zhao Yao 2,Chen Yuanyuan 3,Daru Lu 3 *
1.State Key Laboratory of Genetic Engineering, Fudan-VARI Genetic Epidemiology Center and MOE Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai 200433
2.Neurosurgery Department of Huashan Hospital, Fudan University
3.State Key Laboratory of Genetic Engineering, Fudan-VARI Genetic Epidemiology Center and MOE Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai
*Correspondence author
#Submitted by
Subject:
Funding: Natural Science Foundation of China(No.30800622 and 81001114), This work was partially supported by Shanghai Science and Technology Research Program (No.09JC1402200 and 10410709100), The Project Sponsored by the Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry, Supported by(No.20090071120)
Opened online:10 January 2013
Accepted by: none
Citation: Chen Hongyan,Zhao Yao,Chen Yuanyuan.Sequence Variants on Chromosomes 20q13.33, 11q23.3 and 5p15.33 are Associated with Glioma Susceptibility in a Chinese Population[OL]. [10 January 2013] http://en.paper.edu.cn/en_releasepaper/content/4510854
 
 
Two glioma genome-wide association studies in European populations identified 14 genetic variants strongly associated with risk of glioma, but it is unknown whether these variants associate with glioma risk in Asian populations. The authors genotyped these 14 variants in 976 glioma patients and 1,057 control subjects to evaluate their associations with risk of glioma, particularly high-grade glioma glioblastoma (n=312), in a Chinese population. Overall, we identified three susceptibility loci on 20q13.33 RTEL1 rs6010620 (P=2.79×10?6), 11q23.3 PHLDB1 rs498872 (P=3.8×10?6) and 5p15.33 TERT rs2736100 (P=0.0002) for glioma risk in this study population; also for glioblastoma risk on20q13.33 RTEL1 rs6010620 (P=3.57×10?7), 11q23.3 PHLDB1 rs498872 (P=3.8×10?6), and 5p15.33 TERT rs2736100 and rs2736098 (P=1.21×10?4, 2.84×10?4, respectively). This study provides further evidence of the three glioma susceptibility regions in 20q13.33, 11q23.3 and 5p15.33 in Chinese populations.
Keywords:association; Chinese Han populations; genetic variant; genome-wide association studies;glioma
 
 
 

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