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| IObjective The present study aims to explore the clinical significance of basal reproductive hormones and basal inhibin B in predicting the outcome of AID. Materials and methods A retrospective analysis was performed in 1772 patients undergoing AID, which is being conducted at a department of assisted reproduction from 2009 to 2011. The relationships between basal reproductive hormones (FSH, lutropin, estradiol, progesterone, prolactin and testost) or basal inhibin B and pregnancy rate in AID were assessed. Results: 971 women have access to clinical pregnancy (54.80%) in 1772 women undergoing AID treatment. Found from the analysis of basal reproductive hormones and basal inhibin B shows: ①Basal FSH average in the pregnancy group ( 7.02 ±1.93 mIU / ml) were significantly lower that that in the non-pregnant group (7.27 ± 2.82 mIU/ml); the women with basal FSH ≥ 15 mIU/ml have lower clinical pregnancy rate than those women with basal FSH<15 mIU/ml (P <0.01). ②Basal inhibin B in the pregnancy group (90.61 ± 73.37 ng/ml) were significantly higher than that in the non-pregnant group (79.38 ±49.93 ng / ml); when the basal INHB≥ 25 ng/ml, the clinical pregnancy rate was significantly higher than that with basal INHB ＜25 ng/ml (P <0.05).③To combine the clinical value of ovary reserve with age, FSH* age or inhibin B/ age was used to assess the pregnancy potential. When the level FSH* age climbed above 300, the pregnancy rate decreased significantly; especially when the level of FSH* age reached above 500, the pregnancy rate (14.9%) dropped remarkably. ④With the ratio of inhibin B/age rise, the pregnancy rate was increasing. When the ratio went up to 10, the pregnancy rate was 70.59%. When the ratio inhibin B/age went down to 1, the pregnancy rate(29.3%) decreased significantly. ⑤The basal lutropin, estradiol, progesterone, prolactin and testost have no difference between the pregnancy group and non-pregnant group. Conclusion The present study concludes that basal FSH and basal inhibin B have a close correction with clinical pregnancy rate of AID, which indicate they are biochemical markers for the prediction of outcome of AID. We believe that combine the egg quantity and quanlity (such as FSH*age and inhibin B/age) provides a better tool with which to counsel subfertile couples. |
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| Keywords:basal reproductive hormones; FSH; inhibin B; age; AID |
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