The synergistic regulation of the NODAL gene by transcription factors Smad2 and Cited2 during cardiac development

SUN Lei; LI Hui

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The synergistic regulation of the NODAL gene by transcription factors Smad2 and Cited2 during cardiac development

SUN Lei 1,LI Hui 2 *

1.Departmen t of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang 110004

2.Departmen t of Obstetrics and Gynecology, Shengjing Hospital of China Medical University,Shenyang 110004, China

*Correspondence author

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Funding: 教育部高等学校博士学科点专项科研基金（No.20092104110011）, 辽宁省科学技术计划（No.2011225017）

Opened online:13 March 2013

Accepted by: none

Citation: SUN Lei,LI Hui.The synergistic regulation of the NODAL gene by transcription factors Smad2 and Cited2 during cardiac development[OL]. [13 March 2013] http://en.paper.edu.cn/en_releasepaper/content/4524413

The Nodal signaling pathway has been demonstrated to play a critical role during mammalian cardiac development. As recent tests that have been conducted on gene-targeted mice indicate, its expression is frequently altered where cardiac defects are present. However, the function and the molecular mechanism of Nodal pathway in VSD genesis have not been clarified. In this report, we had revealed decreased NODAL gene expression in patients with supracristal ventricular septal defect, membranous ventricular septal defect, and atrioventricular canal defect compared with the controls. Meanwhile, we found the low expression of CITED2 was associated with low-expression of NODAL gene in VSD tissue. Further study showed Smad2 and Cited2 existed in the same transcriptional complex to regulate the NODAL gene expression by luciferase reporter and co-immunoprecipitation assays. The data presented in this report may contribute to understanding the molecular mechanisms of NODAL regulation, which may be a potential molecular target for halting the onset of VSDs.)

Keywords:NODAL; ventricular septal defects; Smad2 and Cited2

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