Case-control study of FGF20 polymorphism in sporadic Parkinson's disease in Northern Han Chinese

XU Xiaofeng; XU Huamin; XIE Anmu; JIANG Hong; XIE Junxia

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Case-control study of FGF20 polymorphism in sporadic Parkinson's disease in Northern Han Chinese

XU Xiaofeng 1,XU Huamin 2,XIE Anmu 3,JIANG Hong 2,XIE Junxia 2 *

1.Department of Physiology, Medical College of Qingdao University, ShanDong QingDao 266071

2.Department of Physiology, Medical College of Qingdao University

3. Department of Neurology, Af?liated Hospital of Medical College, Qingdao University

*Correspondence author

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Funding: the National Program of Basic Research sponsored by the Ministry of Science and Technology of China （No.2011CB504102）, the National Foundation of Natural Science of China（No.30930036）

Opened online:14 March 2013

Accepted by: none

Citation: XU Xiaofeng,XU Huamin,XIE Anmu.Case-control study of FGF20 polymorphism in sporadic Parkinson's disease in Northern Han Chinese[OL]. [14 March 2013] http://en.paper.edu.cn/en_releasepaper/content/4527523

Fibroblast growth factor 20 (FGF20) is a neurotrophic factor that exerts neurotrophic properties in the brain and could significantly enhance the survival of rat midbrain dopaminergic neurons. The genetic association of the FGF20 gene with Parkinson's disease (PD) remains controversial. Herein we used polymerase chain reaction-restriction length polymorphism assay to assess the association of two single nucleotide polymorphisms (SNPs) rs12720208 and rs1721100 within FGF20 gene in 178 PD patients and 190 healthy controls in Northern Han Chinese. Results showed no significant differences in the rs1721100 or rs12720208 of FGF20 gene between PD cases and the controls. This indicates FGF20 gene might not play a major role in the genetic predisposition to PD in this population.

Keywords:FGF20; Parkinson's disease; SNPs

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