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The Adsorption and Release of DNA by Mesoporous Silica Materials with Different Pore Diameters.
SUN Yan 1 #,YAN Tingsheng 2,LIU Xianbin 3 *
1.Department of Life Science and School of Life Science and Technology, Harbin Institute of Technology, Harbin 150001
2.Department of Life Science and School of Life Science and Technology, Harbin Institute of Technology, Harbin 150001, P. R. China
3.The School of Chemistry and Environmental Engineering, Harbin University of Science and Technology, Harbin 150040, P. R. China
*Correspondence author
#Submitted by
Subject:
Funding: National Science Foundation of China （No.Grants 30900336）, Foundation of State Key Laboratory of Urban water Resource and Environment（No.QAK 200809）, Doctoral Foundation of Ministry of Education of China（No.No. 20092302120070）
Opened online:25 March 2013
Accepted by: none
Citation: SUN Yan,YAN Tingsheng,LIU Xianbin.The Adsorption and Release of DNA by Mesoporous Silica Materials with Different Pore Diameters.[OL]. [25 March 2013] http://en.paper.edu.cn/en_releasepaper/content/4530263
 
 
Safe and efficient vector systems played a crucial role in the transgenic technology. Mesoporous silica (MS) materials, which can be modified with functional groups, have the potential of being used as good vectors. In this study, the pore diameters of synthetic materials were from 2.3 nm to 5.0 nm and the samples have a good dispersion. The MS meterials with different pore diameters were successfully amino-modified and studies about the adsorption and release properties of DNA were carried out. The sample N-MCM-41-14 which had the smallest pore 2.3 nm could only adsorb DNA fragment shorter than 750 bp. The sample N-SBA-15 with 5.0 nm pore could adsorb all DNA fragment shorter than 5000 bp. The pore size of MS materials had important implications on the DNA adsorption rate and the maximum adsorption capacity. However, pore size of the materials had little effect on the release rate of DNA. In sum, MS materials with different pore diameters had different adsorption properties of DNA, and could be as prefect gene delivery systems.
Keywords:mesoporous silica material; pore size; adsorption; release
 
 
 

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