Preparation and properties of the bFGF-loaded collagen/CNCs porous scaffold

LI Weichang; LAN Yong; GUO Rui; ZHANG Yi; XUE Wei; ZHANG Yuanming

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Preparation and properties of the bFGF-loaded collagen/CNCs porous scaffold

LI Weichang 1 #,LAN Yong 2,GUO Rui 3,ZHANG Yi 3,XUE Wei 3,ZHANG Yuanming 2 *

1.Department of Chemistry, Jinan University, GuangZhou 510632

2.Department of Chemistry, Jinan University, Guangzhou 510632, China

3.Institutes of Life and Health Engineering, Jinan University, Guangzhou 510632, China

*Correspondence author

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Funding: none

Opened online:27 April 2013

Accepted by: none

Citation: LI Weichang,LAN Yong,GUO Rui.Preparation and properties of the bFGF-loaded collagen/CNCs porous scaffold[OL]. [27 April 2013] http://en.paper.edu.cn/en_releasepaper/content/4539403

Rod-like cellulose nanocrystals (CNCs) were manufactured and used to reinforce collagen scaffolds, to prepare a novel structure of composite scaffold. Collagen is the main component of skin and connective tissue found exclusively in body. The CNCs-loaded collagen scaffolds had improved structural stabilities. Structural stabilities are essential considerations for the design of composite in the field of tissue engineering. We have used a variety of experimental techniques to investigate the properties of the collagen/CNCs scaffolds at different mixing proportion. The objective was to observe the differences of collagen scaffold and collagen/CNCs scaffold in the swelling behaviour and thermostability. In addition, we describe the incorporation of bFGF-gelatin microspheres into collagen/CNCs scaffolds and study the release kinetics of basic fibroblast growth factor (bFGF) as a function of scaffold properties. With these abilities indicate that our new composite scaffold have good potential in the field of skin tissue engineering.

Keywords:composite scaffolds; cellulose nanocrystals (CNCs); collagen; bFGF

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