Erk1/2 Signaling Is Involved in the Differentiation of Periodontal Ligament Stem Cells to Schwann Cells in Dog

LIAO Dapeng; LI Xiaojie; GONG Ping; DONG Yan; SUN Gang

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Erk1/2 Signaling Is Involved in the Differentiation of Periodontal Ligament Stem Cells to Schwann Cells in Dog

LIAO Dapeng 1 #,LI Xiaojie 2 *,GONG Ping 3,DONG Yan 4,SUN Gang 4

1.Department of Dentistry,Second Affiliated Hospital,School of Medicine,Zhejiang University, Hangzhou 310009

2.Department of Dentistry, Sir Run Run Shaw Hospital, School of Medicine,Zhejiang University

3.Dental Implant Center,West China College of Stomatology, Sichuan University, ChengDu 610041

4.Department of Dentistry,Second Affiliated Hospital,School of Medicine,Zhejiang University,Hangzhou 310009

*Correspondence author

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Funding: The Research Fund for New Teachers in the Doctoral Program of Higher Education, Ministry of Education, China （No.No. 491020-A51208）, The Zhejiang Province Natural Science Foundation （No.No. 491020+N21129）, National Natural Science Foundation of China （No.NO.30772448）

Opened online:29 July 2013

Accepted by: none

Citation: LIAO Dapeng,LI Xiaojie,GONG Ping.Erk1/2 Signaling Is Involved in the Differentiation of Periodontal Ligament Stem Cells to Schwann Cells in Dog[OL]. [29 July 2013] http://en.paper.edu.cn/en_releasepaper/content/4552913

Objective: To explore the potential role of Erk1/2 signaling pathway in the differentiation of periodontal ligament stem cells (PDLSCs) to Schwann cells (SCs). Method: When PDLSCs were induced to differentiate to SCs, the cells were treated with U0126, an Erk1/2 pathway specific inhibitor, and its potential effect on SC differentiation was appraised using Western-blotting, immunostaining, and reverse transcriptase PCR.Results: Specifically inhibiting the Erk1/2 signaling pathway reduced the expression of SC-specific marker genes, S100, GFAP, and P75 and SC differentiation regulators, krox-20, Oct-6, and P0 in the cells undergoing induced differentiation from PDLSCs. Conclusion: The Erk1/2 signaling pathway is involved in the induced differentiation of PDLSCs to SCs.

Keywords:Erk1/2 signaling pathway; differentiation; periodontal ligament stem cells; Schwann cells

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