Changes of proteins induced by anticoagulants can be more sensitively detected in urine than in plasma

Li Menglin; Zhao Mindi; Gao Youhe

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Changes of proteins induced by anticoagulants can be more sensitively detected in urine than in plasma

Li Menglin,Zhao Mindi,Gao Youhe *

Department of Physiology and Pathophysiology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Beijing 100005, China

*Correspondence author

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Funding: the National Basic Research Program of China （No.2012CB517606, 2013CB530805), Program for Chang jiang Scholars and Innovative Research Team in University-PCSIRT）

Opened online:15 November 2013

Accepted by: none

Citation: Li Menglin,Zhao Mindi,Gao Youhe.Changes of proteins induced by anticoagulants can be more sensitively detected in urine than in plasma[OL]. [15 November 2013] http://en.paper.edu.cn/en_releasepaper/content/4568383

Biomarker studies commonly monitor the composition of plasma, which is under strict homeostatic control, while urine is not. Urine is a partial filtrate of blood; however, its composition reflects systemic physiology. Here we show that changes in the coagulation status of blood can be more sensitively detected in urine than in plasma. Plasma and urine protein composition was analysed by LC-MS/MS and Western blot in six SD female rats before and after treatment with heparin or argatroban. LC-MS/MS and Western blot analyses demonstrated drug-induced increases in transferrin and hemopexin levels in urine but not in plasma. Our data indicates that urine may serve as a source for more sensitive detection of protein biomarkers than plasma.

Keywords:bioscience; biomarker; urine; plasma; proteomics

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