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| Naphtho[2,1-a]pyrrolo[3,4-c]carbazole-5,7(6H,12H)-dione (NPCD) is known to be a very potent and selective cyclin D1-CDK4 inhibitors and could induce strong G1 phase arrest in breast tumor cell lines. In this work, the synthesis and biological evaluation of cytotoxic activity of a novel NPCD glycoside, 14-(α-L-rhamnopyranosyl)-naphtho[2,1-a]pyrrolo[3,4-c] carbazole-5,7 (6H,12H)- dione (1) were reported. The results showed the NPCD glycoside 1 displayed strong tumor cell growth inhibitory activities in the range of micromolar IC50 towards a broad spectrum of tumor cell lines. Analysis of cell cycle profiles revealed that NPCD glycoside 1 arrested the cells at different phases depending on the cell lines.) |
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| Keywords:indolocarbazole; cytotoxicity; rebeccamycin; cell-cycleglycoside |
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