Preparation and evaluation of Angiopep-2 peptide grafted micelle for brain targeting delivery

QUAN Yi; JIN Mingji; LI Yunfei; WANG Qiming; SHAO Rongguang; GAO Zhonggao

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Preparation and evaluation of Angiopep-2 peptide grafted micelle for brain targeting delivery

QUAN Yi 1,JIN Mingji 1,LI Yunfei 2,WANG Qiming 1,SHAO Rongguang 2,GAO Zhonggao 1 *

1.Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China

2.Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China

*Correspondence author

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Funding: Specialized Research Fund for the Doctoral Program of Higher Education （No.No. 20101106110031）

Opened online:26 January 2014

Accepted by: none

Citation: QUAN Yi,JIN Mingji,LI Yunfei.Preparation and evaluation of Angiopep-2 peptide grafted micelle for brain targeting delivery[OL]. [26 January 2014] http://en.paper.edu.cn/en_releasepaper/content/4583312

In this paper, a novel drug-loaded micelle for brain targeting delivery was developed by conjugating the targetable moiety Angiopep-2 peptide on the surface of micelle. In order to monitoring the size of the tumor inside of the brain after treatment, the technique of bioluminescence imaging in living rats was developed. The luciferase-labelled glioma cell line C6-Luc was firstly constructed through cell transfection and monoclone screening, and then evaluated by luciferase reporter assay. The anti-glioma effect of Doxorubicin-loaded targetable micelle was assessed through cell MTT assay and determining the survival time of glioma bearing rats. The results demonstrated that such Doxorubicin-loaded targetable micelle showed a strong anti-glioma effect, and it could significantly prolong the life span of glioma bearing rats, which suggested that Angiopep-2 modified micelles is a promising carrier for drug brain targeting delivery.

Keywords:pharmaceutics; micelle; Angiopep-2 peptide; glioma; bioluminescence imaging; tumor therapy

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